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Total 5210 results found since Jan 2013.

Vascular effects of biologic and targeted synthetic antirheumatic drugs approved for rheumatoid arthritis: a systematic review
CONCLUSION: Overall, our systematic review provides important insights into the potential cardiovascular benefits of biologic and targeted synthetic treatments for RA by a still unknown mechanism. These findings can inform clinical practice and contribute to our understanding of their possible effects on early vascular pathology. Key Points • Great heterogeneity of methods are used to evaluate the endothelial function and arterial stiffness in patients with RA on biologic and targeted synthetic antirheumatic drugs. • Most studies have shown a considerable improvement in endothelial function and arterial stiffness with ...
Source: Atherosclerosis - March 29, 2023 Category: Cardiology Authors: Georgi Gerganov Tsvetoslav Georgiev Maria Dimova Tanya Shivacheva Source Type: research

Rituximab use in adult glomerulopathies and its rationale.
Authors: Santos JE, Fiel D, Santos R, Vicente R, Aguiar R, Santos I, Amoedo M, Pires C Abstract Glomerulopathies are one of the leading causes of end-stage renal disease. In the last years, clinical research has made significant contributions to the understanding of such conditions. Recently, rituximab (RTX) has appeared as a reasonably safe treatment. The Kidney Disease: Improving Global Outcomes guidelines (KDIGO) recommended RTX only as initial treatment in antineutrophil cytoplasm antibody associated vasculitis (AAV) and in non-responders patients with lupus nephritis (LN), but these guidelines have not been up...
Source: Jornal Brasileiro de Nefrologia - January 8, 2020 Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research

Bone marrow vascular endothelial growth factor level per platelet count might be a significant predictor for the treatment outcomes of patients with diffuse large B-cell lymphomas
Conclusions Bone marrow plasma vascular endothelial growth factor level per platelet count might be associated with bone marrow invasion by diffuse large B-cell lymphoma and is correlated with clinical outcomes after treatment.
Source: Japanese Journal of Clinical Oncology - September 29, 2015 Category: Cancer & Oncology Authors: Kim, J. S., Gang, G. W., Lee, S. R., Sung, H. J., Park, Y., Kim, D. S., Choi, C. W., Kim, B. S. Tags: Hematology, Original Articles Source Type: research

The effect of non-TNF-targeted biologics on vascular dysfunction in rheumatoid arthritis: A systematic literature review
ConclusionNon-TNF-targeted biologics have been associated with favorable effects on endothelial dysfunction as already demonstrated for TNF inhibitors. Future studies are needed to ascertain the impact of this mediations on arterial stiffness in RA patients.
Source: Autoimmunity Reviews - March 5, 2019 Category: Allergy & Immunology Source Type: research

Multicentric Castleman disease of hyaline vascular variant presenting with unusual systemic manifestations: a case report
ConclusionsCastleman disease has a broad spectrum of clinical manifestations, disease pathogeneses, and associations and/or complications. Medical professionals need to be familiar with this spectrum because timely diagnosis and aggressive targeted therapy are the cornerstones of managing these patients.
Source: Journal of Medical Case Reports - May 14, 2017 Category: General Medicine Source Type: research

The Elevation of Cardio-Ankle Vascular Index in a Patient With Malignant Lymphoma Treated With a Combination Therapy of Rituximab and Cyclophosphamide, Doxorubicin, Vincristine, and Prednisolone.
Abstract An increased risk of arteriosclerosis has been noted in cancer survivors. Currently, there are only a few reports available that consider the risk of arteriosclerosis in patients treated with chemotherapy. Patients with an advanced stage B-cell malignant lymphoma are typically treated with a combination therapy of rituximab and cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP). Complications such as diabetes mellitus (DM), hyperlipidemia (HL), and osteoporosis due to prednisolone and cardiotoxicity due to anthracyclines are well known. However, there are no studies that have investigat...
Source: Clin Med Res - July 21, 2017 Category: Research Authors: Shimizu N, Ban N, Watanabe Y, Rikitake A, Watanabe R, Tanaka S, Sato Y, Imamura H, Kawana H, Yamaguchi T, Saiki A, Tatsuno I, Shirai K Tags: J Clin Med Res Source Type: research

The Cerebrospinal Fluid in Multiple Sclerosis
Conclusions OCB are important biomarkers that can support MRI diagnostics and help to avoid false-positive MS diagnoses. Therefore, the revised McDonalds criteria have increased the importance of the OCB. New biomarkers such as AQP4 have now established themselves in clinical practice, and others such as Anti-MOG and NfL are about to enter clinical routine. An important focus in the search for new biomarkers is the monitoring of therapy efficacy and the prediction of severe side effects. Many other CSF molecules such as CHI3L1, IL-6, or CXCL13 show potential as markers for clinical practice, but further research is nee...
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research

From “Serum Sickness” to “Xenosialitis”: Past, Present, and Future Significance of the Non-human Sialic Acid Neu5Gc
Conclusions and Perspectives In this review, we have discussed important milestones from the early description of “Serum-sickness” as being due to antibodies directed against Neu5Gc epitopes all the way to the present-day therapeutic implications of these antibodies in cancer therapy. Some of these milestones have been represented in a concise timeline (Figure 6). While the “Xenosialitis” hypothesis is well-supported in the human-like mouse models, it has yet to be conclusively proven in humans. It remains to be seen if “Xenosialitis” plays a role in other uniquely-human dis...
Source: Frontiers in Immunology - April 16, 2019 Category: Allergy & Immunology Source Type: research

Understanding Pathogenesis Intersects With Effective Treatment for Thyroid Eye Disease
CONCLUSION: Despite their current wide use, steroids may no longer enjoy first-tier status for TED as more effective and better tolerated medical options become available. Multiple current and emerging therapies, the rationales for which are rooted in theoretical and experimental science, promise better options. These include teprotumumab, rituximab, and tocilizumab. Restoration of immune tolerance could ultimately become the most effective and safe medical management for TED.PMID:36346686 | PMC:PMC9359447 | DOI:10.1210/clinem/dgac328
Source: The Journal of Clinical Endocrinology and Metabolism - November 8, 2022 Category: Endocrinology Authors: Terry J Smith Source Type: research

Neuro‐ophthalmologic manifestations of systemic lupus erythematosus: a systematic review
Abstract Herein we summarize the clinical presentation, treatment and outcome of neuro‐ophthalmologic manifestations in patients with systemic lupus erythematosus (SLE). We performed a systematic review of the neuro‐ophthalmologic manifestations of SLE reported in the English literature from 1970 to 2010 by a Medline search. The prevalence of neuro‐ophthalmologic manifestations is 3.6% in adult and 1.6% in childhood SLE patients. Neuro‐ophthalmologic manifestations of SLE are highly variable, with the commonest presentation being optic neuritis, followed by myasthenia gravis, visual field defects and pseudotumor ce...
Source: APLAR Journal of Rheumatology - March 27, 2014 Category: Rheumatology Authors: Bik Ling Man, Chi Chiu Mok, Yat Pang Fu Tags: Review Article Source Type: research

A Systematic Review on Predisposition to Lymphoid (B and T cell) Neoplasias in Patients With Primary Immunodeficiencies and Immune Dysregulatory Disorders (Inborn Errors of Immunity)
Conclusions Though this is not a comprehensive summary of malignancies in PIDDs, or even lymphoproliferative disease in this area, this review summarizes the Medline-indexed published reports of B and T lymphomas in patients with PIDDs. This report highlights the diversity of malignant lymphoproliferative disorders in setting of PIDDs, and its associated challenges of diagnosis and treatment. The pathological classification and nomenclature for the lymphoid malignancies with variably reported and postulated underlying mechanisms were inconsistent and inadequate for many of these published reports. A wide range of treatmen...
Source: Frontiers in Immunology - April 15, 2019 Category: Allergy & Immunology Source Type: research

Immunosuppressive therapy of systemic lupus erythematosus associated peripheral neuropathy: A systematic review.
CONCLUSIONS: There are no interventional studies dedicated to the SLE associated PN, only retrospective case reports or case series which not only did they show contradictory results, but they also represent the lowest level of evidence. There is a strong need for new analytical studies dedicated to SLE associated PN.Protocol registered with PROSPERO (number CRD42019121748). PMID: 32757735 [PubMed - as supplied by publisher]
Source: Lupus - August 4, 2020 Category: Rheumatology Authors: Constantin A, Năstase D, Tulbă D, Bălănescu P, Băicuș C Tags: Lupus Source Type: research

Immunosuppressive treatment for primary membranous nephropathy in adults with nephrotic syndrome
CONCLUSIONS: This updated review strengthened the evidence that immunosuppressive therapy is probably superior to non-immunosuppressive therapy in inducing remission and reducing the number of patients that progress to ESKD. However, these benefits need to be balanced against the side effects of immunosuppressive drugs. The number of included studies with high-quality design was relatively small and most studies did not have adequate follow-up. Clinicians should inform their patients of the lack of high-quality evidence. An alkylating agent (cyclophosphamide or chlorambucil) combined with a corticosteroid regimen had short...
Source: Cochrane Database of Systematic Reviews - November 15, 2021 Category: General Medicine Authors: Thilo C von Groote Gabrielle Williams Eric H Au Yizhi Chen Anna T Mathew Elisabeth M Hodson David J Tunnicliffe Source Type: research